M E D I A A L E R T For Information Contact: Joni Morford, Communicore 714/721-8081 jmorford@communicore.com CONFERENCE HIGHLIGHTS REVOLUTIONARY NEW FIELD OF ORTHOBIOLOGICS FOR BONE, CARTILAGE, AND SKIN REGENERATION Orquest, Inc. Presentation Focuses on New Materials for Improving Spinal Fusion and Accelerating Fracture Healing WHO: James W. Poser, Ph.D., Vice President of Research and Development at Orquest, Inc., a Mountain View-Calif. company developing a portfolio of orthobiologic products for bone and cartilage regeneration. WHAT: "New Matrices and Agents for Bone Repair" will be presented at the Advancements in Tissue Engineering: New Developments in Cartilage, Skin and Bone Engineering conference in Boston. Dr. Poser, a conference chairperson, will discuss Orquest's two orthobiologic products in development--Healosª, an implantable bone graft alternative to autograft for spinal fusion, and Ossigelª, an injectable matrix for accelerated fracture healing. WHY: The conference will bring together a range of experts for one of the first meetings focusing on the new field of orthobiologics. Orthobiologics combines an understanding of tissue biology, material sciences, and a new generation of growth factors to create breakthrough orthopedic therapies. Orquest is a pioneer in this new field, developing approaches to bone and cartilage regeneration that use naturally occurring biomaterials that mimic the body's natural tissue environment. These new therapeutic options have the potential to reduce morbidity and hospital stays associated with current procedures, resulting in improved patient quality of life and reduced healthcare costs. Orquest's Healos was designed to eliminate autograft--a painful and expensive secondary surgery routinely performed in spinal fusion. Healos provides a "scaffolding" for bone ingrowth and is completely replaced by new bone as part of the body's natural healing process. Orquest's second technology, Ossigel, accelerates fracture healing. These technologies may be able to help the more than 200,000 patients who undergo spinal fusion procedures and 6 million people who suffer bone fractures in the United States each year. WHERE: The Copley Plaza Hotel, Boston WHEN: Thursday, June 26, 1997; 11:25-11:55 a.m. Note to Editors: Dr. Poser will be in the Boston area and available for interviews June 26-27, 1997. Thomas A. Einhorn, M.D., Professor & Chairman of the Department of Orthopaedic Surgery at Boston University School of Medicine, is also available. Dr. Einhorn, an expert in orthopedic surgery, offers a clinical perspective on the potential benefits of orthobiologic approaches. End of document.